DyDTPA-BMA和GdDTPA-BMA在正常和缺血猫脑的脑血管转运特性

Cerebrovascular transit characteristics of DyDTPA-BMA and GdDTPA-BMA on normal and ischemic cat brain.

作者信息

Kucharczyk J, Asgari H, Mintorovitch J, Vexler Z, Rocklage S, Watson A, Moseley M

机构信息

Neuroradiology Section, University of California, San Francisco.

出版信息

AJNR Am J Neuroradiol. 1993 Mar-Apr;14(2):289-96.

PMID:8456701

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8332934/

Abstract

PURPOSE

To compare the efficacy of two nonionic T2*-shortening contrast agents, DyDTPA-BMA dysprodiamide injection and GdDTPA-BMA gadodiamide injection, as perfusion-sensitive MR imaging agents in normal and acutely ischemic brain.

METHODS

The magnetic susceptibility effects of intravenous injections of 0.10-0.50 mmol/kg of each contrast agent were quantified on T2-weighted spin-echo images of cat brain before and after unilateral occlusion of the middle cerebral artery by measuring signal intensity changes in the same regions-of-interest in parietal cortex.

RESULTS

In normal brain, DyDTPA-BMA produced a significantly greater loss of signal intensity than equimolar doses of GdDTPA-BMA. The magnitude of the signal intensity attenuation was dosage-dependent and proportional to the square of the magnetic moments of the two contrast agents. Restoration of baseline image signal intensity was observed within 30 min after each injection. However, injection of GdDTPA-BMA also produced a delayed, persistent hyperintensity on T2-weighted images, presumably due to its underlying T1-shortening effect. Following unilateral occlusion of the middle cerebral artery, unenhanced T2-weighted images failed to show evidence of cerebral injury for 1.5-3 hours. Administration of 0.10-1.0 mmol/kg DyDTPA-BMA shortened the time for detection of perfusion deficits (residual hyperintensity) in 22 of 36 (61%) treated cats, often to within 30 min after arterial occlusion. DyDTPA-BMA enhancement also improved lesion conspicuity in 26 of 36 (72%) cases, and disclosed very small infarcts that were not visible on T2-weighted precontrast images. Perfusion deficits in areas of partial ischemia were seen more clearly on DyDTPA-BMA-enhanced images than after equimolar injections of GdDTPA-BMA.

CONCLUSIONS

Magnetic susceptibility contrast-enhanced MR imaging enables detection of perfusion deficits associated with acute cerebral ischemia well in advance of conventional T2-weighted spin-echo MR imaging without contrast. DyDTPA-BMA appears to delineate regions of ischemic damage better than GdDTPA-BMA.

摘要

目的

比较两种非离子型T2*缩短造影剂——钆喷酸葡胺双甲胺注射液（DyDTPA - BMA）和钆双胺注射液（GdDTPA - BMA）作为灌注敏感型磁共振成像剂在正常和急性缺血性脑内的效能。

方法

通过测量顶叶皮质相同感兴趣区域的信号强度变化，在大脑中动脉单侧闭塞前后，对猫脑的T2加权自旋回波图像上静脉注射0.10 - 0.50 mmol/kg每种造影剂的磁化率效应进行量化。

结果

在正常脑内，DyDTPA - BMA产生的信号强度损失明显大于等摩尔剂量的GdDTPA - BMA。信号强度衰减的幅度与剂量相关，且与两种造影剂磁矩的平方成正比。每次注射后30分钟内观察到基线图像信号强度恢复。然而，注射GdDTPA - BMA在T2加权图像上也产生了延迟的、持续的高信号，可能是由于其潜在的T1缩短效应。大脑中动脉单侧闭塞后，未增强的T2加权图像在1.5 - 3小时内未显示脑损伤迹象。给予0.10 - 1.0 mmol/kg的DyDTPA - BMA缩短了36只接受治疗猫中22只（61%）检测灌注缺损（残留高信号）的时间，通常在动脉闭塞后30分钟内。DyDTPA - BMA增强在36例中的26例（72%）中也改善了病变的清晰度，并揭示了在T2加权对比前图像上不可见的非常小的梗死灶。与等摩尔注射GdDTPA - BMA相比，在DyDTPA - BMA增强图像上部分缺血区域的灌注缺损更清晰可见。