Stöss H, Freisinger P
Department of Pathology, University of Erlangen, Germany.
Am J Med Genet. 1993 Jan 15;45(2):257. doi: 10.1002/ajmg.1320450220.
Comprehensive electron-microscopic studies showed that the structure of the collagen fibrils in the osteoid is not uniform. In 82 cases of osteogenesis imperfecta (OI), the diameter of the collagen fibrils was determined morphometrically under standardized magnification. The morphometric investigations of collagen fibrils of the osteoid in OI show clear differences in the four subtypes and in comparison with the control group.
全面的电子显微镜研究表明,类骨质中胶原纤维的结构并不均匀。在82例成骨不全症(OI)病例中,在标准化放大倍数下对胶原纤维的直径进行了形态计量学测定。对OI中类骨质的胶原纤维进行的形态计量学研究显示,在四个亚型中以及与对照组相比存在明显差异。