Pratt D, Novotny M, Kaberlein G, Dudkiewicz A, Gleicher N
Center for Human Reproduction, Chicago, IL 60610.
Am J Obstet Gynecol. 1993 Mar;168(3 Pt 1):837-41. doi: 10.1016/s0002-9378(12)90830-3.
The purpose of our study was to evaluate the incidence of antithyroid antibodies and non-organ-specific antibodies in women who have had three or more recurrent spontaneous abortions.
Sera from 45 women for the presence of antithyroid antibodies to thyroglobulin and thyroid peroxide and for the non-organ-specific autoantibodies to 6 phospholipids, 5 histones, and 4 polynucleotides were analyzed. Sera from 100 apparently health blood donors served as controls.
The test results of 14 (31%) of 45 study subjects were positive for one or both antithyroid antibodies compared with 19 (19%) of controls. Five (11%) of 45 patients had positive test results for one or more non-organ-specific antibodies, and 4 (8%) of 45 had positive test results for the lupus anticoagulant by either activated partial thromboplastin, tissue thromboplastin time, or both. Only 3 (21%) of 14 subjects whose test results were positive for thyroid antibodies also demonstrated non-organ-specific autoantibodies.
The incidence of antithyroid antibodies in women who have had recurrent abortions appears not to be significantly increased compared with a normal random control population. Antithyroid antibodies do occur, however, with significantly greater frequencies in women with recurrent spontaneous abortions than non-organ-specific autoantibodies (p = 0.02). Organ-specific and non-organ-specific autoantibodies may serve as independent markers of risk for repeated pregnancy loss in patient populations where pregnancy loss is associated with abnormal autoimmune function.
我们研究的目的是评估有三次或更多次反复自然流产的女性中抗甲状腺抗体和非器官特异性抗体的发生率。
分析了45名女性血清中抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体以及针对6种磷脂、5种组蛋白和4种多核苷酸的非器官特异性自身抗体的存在情况。100名明显健康的献血者血清作为对照。
45名研究对象中有14名（31%）一种或两种抗甲状腺抗体检测结果呈阳性，而对照组为19名（19%）。45名患者中有5名（11%）一种或多种非器官特异性抗体检测结果呈阳性，45名中有4名（8%）通过活化部分凝血活酶时间、组织凝血活酶时间或两者检测狼疮抗凝物呈阳性。在14名甲状腺抗体检测结果呈阳性的受试者中，只有3名（21%）也表现出非器官特异性自身抗体。
与正常随机对照人群相比，反复流产女性中抗甲状腺抗体的发生率似乎没有显著增加。然而，反复自然流产女性中抗甲状腺抗体的出现频率明显高于非器官特异性自身抗体（p = 0.02）。在妊娠丢失与自身免疫功能异常相关的患者群体中，器官特异性和非器官特异性自身抗体可能作为反复妊娠丢失风险的独立标志物。
