Kammerer C M, Hixson J E, Mott G E
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78228.
Atherosclerosis. 1993 Jan 25;98(2):153-63. doi: 10.1016/0021-9150(93)90125-e.
We investigated the effects of a polymorphic PvuII site in the gene for lecithin:cholesterol acyltransferase (LCAT) on serum high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (apo A-I) concentrations in a population of 750 pedigreed baboons. We also tested for genotype by diet interactions using data on HDL-C and apo A-I concentrations on two diets (chow and high-cholesterol, saturated fat). A significant (P < 0.001) association between the LCAT genotypes and HDL-C levels was observed. On both diets, animals homozygous for the less common allele had HDL-C levels that averaged 18-19% lower than animals homozygous for the more common allele. HDL-C levels of the heterozygotes were intermediate. The LCAT RFLP accounted for approximately 5% of the variation in HDL-C levels on the two diets. We observed no strong evidence for an LCAT genotype by diet interaction effect.
我们在750只纯种狒狒群体中研究了卵磷脂胆固醇酰基转移酶（LCAT）基因中一个多态性PvuII位点对血清高密度脂蛋白胆固醇（HDL-C）和载脂蛋白A-I（apo A-I）浓度的影响。我们还利用两种饮食（普通饲料和高胆固醇、饱和脂肪饲料）的HDL-C和apo A-I浓度数据，测试了基因型与饮食的相互作用。观察到LCAT基因型与HDL-C水平之间存在显著关联（P < 0.001）。在两种饮食中，携带较罕见等位基因的纯合动物的HDL-C水平平均比携带较常见等位基因的纯合动物低18 - 19%。杂合子的HDL-C水平处于中间。LCAT限制性片段长度多态性（RFLP）在两种饮食中约占HDL-C水平变异的5%。我们没有观察到关于LCAT基因型与饮食相互作用效应的有力证据。
