Synthesis and pharmacological activity of imidazo[2,1-b]benzothiazole acids.
作者信息
Grandolini G, Ambrogi V, Perioli L, de Caprariis P, Palagiano F, Rimoli M G, Lampa E, D'Amico M
机构信息
Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Facoltà di Farmacia, Università di Perugia.
出版信息
Farmaco. 1993 Jan;48(1):31-43.
PMID:8457278
Abstract
We have prepared twelve imidazo[2,1-b]benzothiazole carboxylic and acetic acids by reaction of substituted 2-aminobenzothiazoles with ethyl bromopyruvate and 4-chloroacetoacetate, respectively. The acids, obtained from esters by hydrolysis, were tested for their antiinflammatory, analgesic and ulcerogenic activities.
摘要
Zotero 插件