Faraj A H, Morley A R
Northern Counties Kidney Research Fund, Medical School, Newcastle upon Tyne, UK.
APMIS. 1993 Jan;101(1):83-90. doi: 10.1111/j.1699-0463.1993.tb00085.x.
In Wistar male rats, hypertension was induced by 5/6 nephrectomy (5/6N). Electron microscopy revealed an increase in the number of epithelial cells on the Bowman's capsule during the early stages (4 weeks). After 8 and 12 weeks, frequent adhesion was observed between the glomerular tuft and Bowman's capsule. The abnormal podocytes showed nuclear irregularities and distortions. Characteristic foot process fusion formed cytoplasmic plates. There was a considerable increase in mesangial matrix and cells. No immune deposits or breaks in the glomerular basement membrane were observed. In the endothelial cells, the fenestration disappeared in sclerosed glomeruli. Some capillary loops were obliterated by fibrin, macrophages and foam cells. These findings combined with our previous light microscopy and immunofluorescent observations suggest a non-immunogenic glomerular sclerosis.
在雄性Wistar大鼠中，通过5/6肾切除术（5/6N）诱导高血压。电子显微镜检查显示，在早期阶段（4周），鲍曼囊上皮细胞数量增加。8周和12周后，观察到肾小球毛细血管丛与鲍曼囊之间频繁粘连。异常的足细胞显示核不规则和变形。特征性的足突融合形成细胞质板。系膜基质和细胞显著增加。未观察到免疫沉积物或肾小球基底膜破裂。在内皮细胞中，硬化肾小球中的窗孔消失。一些毛细血管袢被纤维蛋白、巨噬细胞和泡沫细胞阻塞。这些发现与我们之前的光学显微镜和免疫荧光观察结果相结合，提示为非免疫性肾小球硬化。
