（吡咯烷酮-5-异羟肟酸）铁（III）螯合物的稳定性

Stability of (pyrrolidone-5-hydroxamato)iron (III) chelates.

作者信息

Pećar M, Kujundzić N, Pazman J

出版信息

J Pharm Sci. 1977 Mar;66(3):330-3. doi: 10.1002/jps.2600660306.

Abstract

Overall stability constants of mono-, bis-, and tris(pyrrolidone-k-hydroxamato)iron(III) chelates were determined in aqueous solutions at 25 degrees as log beta1=1.49, log beta11=1.55, and log betaIII=0.21, respectively, where beta1=[Fe(C5H7O3N2)2+][H+]/[F=E3+][HC5H7O3N2], betaII=[Fe(C5H7O3N2)2+][H+]2/[Fe3+][hc5h7o3n2]2, and betaIII=[Fe(C5H7O3N2)3][H+]3/[Fe3+][HC5H7O3N2]3. Stability constants of all three chelates were determined potentiometrically in the 3.00-3.23 pH region. The stability constant of the mono chelate also was determined spectrophotometrically at 25 degrees as log beta1-1.52 by measuring absorbance at 500 nm (absorbance maximum), where the molar absorptivity was epsilon=1124 liters/(mole cm). Biological implications of hydroxamic acid-containing compounds are discussed.

摘要

在25摄氏度的水溶液中测定了单（吡咯烷酮 - k - 异羟肟酸）铁（III）、双（吡咯烷酮 - k - 异羟肟酸）铁（III）和三（吡咯烷酮 - k - 异羟肟酸）铁（III）螯合物的总稳定常数，分别为logβ1 = 1.49、logβII = 1.55和logβIII = 0.21，其中β1 = [Fe(C5H7O3N2)2 + ][H + ]/[Fe3 + ][HC5H7O3N2]，βII = [Fe(C5H7O3N2)2 + ][H + ]2/[Fe3 + ][hc5h7o3n2]2，βIII = [Fe(C5H7O3N2)3][H + ]3/[Fe3 + ][HC5H7O3N2]3。所有三种螯合物的稳定常数在3.00 - 3.23的pH范围内通过电位滴定法测定。单螯合物的稳定常数在25摄氏度时也通过分光光度法测定，通过测量500nm（最大吸收波长）处的吸光度得出logβ1 = 1.52，其中摩尔吸光系数为ε = 1124升/（摩尔·厘米）。讨论了含异羟肟酸化合物的生物学意义。