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Synthesis of low-toxicity, 5-deoxy-5-fluoro and 5-deoxy-5,5-difluoro derivatives of arbekacin and its analogs, and study of structure-toxicity relationships.

作者信息

Tsuchiya T, Shitara T, Umezawa S, Takeuchi T, Hamada M, Tomono N, Umemura E

机构信息

Institute of Bioorganic Chemistry, Kawasaki, Japan.

出版信息

Carbohydr Res. 1993 Feb 24;240:307-12. doi: 10.1016/0008-6215(93)84194-b.

DOI:10.1016/0008-6215(93)84194-b
PMID:8458012
Abstract
摘要

相似文献

1
Synthesis of low-toxicity, 5-deoxy-5-fluoro and 5-deoxy-5,5-difluoro derivatives of arbekacin and its analogs, and study of structure-toxicity relationships.
Carbohydr Res. 1993 Feb 24;240:307-12. doi: 10.1016/0008-6215(93)84194-b.
2
Synthesis of 5-deoxy-5-epifluoro derivatives of arbekacin, amikacin, and 1-N-[(S)-4-amino-2-hydroxybutanoyl]tobramycin (study on structure--toxicity relationships).
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Synthesis of 1-N-[(2S,4S)- and (2S,4R)-5-amino-4-fluoro-2-hydroxypentanoyl]dibekacins (study on structure-toxicity relationships).
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4
Synthesis and antibacterial activity of 5-deoxy-5-episubstituted arbekacin derivatives.
Bioorg Med Chem Lett. 2007 Jul 1;17(13):3540-3. doi: 10.1016/j.bmcl.2007.04.065. Epub 2007 Apr 25.
5
Synthesis of 2"-oxidized derivatives of 5-deoxy-5-epi-5-fluoro-dibekacin and -arbekacin, and study on structure-chemical shift relationships of urethane(or amide)-type NH protons in synthetic intermediates.
Carbohydr Res. 1997 Mar 13;298(4):261-77. doi: 10.1016/s0008-6215(96)00318-7.
6
Effect of varying the 4''-position of arbekacin derivatives on antibacterial activity against MRSA and Pseudomonas aeruginosa.阿贝卡星衍生物4''-位结构变化对耐甲氧西林金黄色葡萄球菌和铜绿假单胞菌抗菌活性的影响。
Bioorg Med Chem Lett. 2007 Nov 15;17(22):6369-72. doi: 10.1016/j.bmcl.2007.08.059. Epub 2007 Aug 28.
7
A newly recognized acetylated metabolite of arbekacin in arbekacin-resistant strains of methicillin-resistant Staphylococcus aureus.
J Antimicrob Chemother. 1998 Apr;41(4):495-7. doi: 10.1093/jac/41.4.495.
8
New 2''-amino derivatives of arbekacin, potent aminoglycoside antibiotics against methicillin-resistant Staphylococcus aureus.阿贝卡星的新型2''-氨基衍生物，对耐甲氧西林金黄色葡萄球菌有效的氨基糖苷类抗生素。
J Antibiot (Tokyo). 1993 Mar;46(3):531-4. doi: 10.7164/antibiotics.46.531.
9
The novel enzymatic 3''-N-acetylation of arbekacin by an aminoglycoside 3-N-acetyltransferase of Streptomyces origin and the resulting activity.来自链霉菌的氨基糖苷3-N-乙酰基转移酶对阿贝卡星进行的新型酶促3''-N-乙酰化作用及由此产生的活性。
J Antibiot (Tokyo). 1998 Aug;51(8):735-42. doi: 10.7164/antibiotics.51.735.
10
Synthesis of 2''-amino-2''-deoxyarbekacin and its analogs having potent activity against methicillin-resistant Staphylococcus aureus.2''-氨基-2''-脱氧阿贝卡星及其对耐甲氧西林金黄色葡萄球菌具有强效活性的类似物的合成。
J Antibiot (Tokyo). 1994 Jul;47(7):821-32. doi: 10.7164/antibiotics.47.821.

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Aminoglycosides: nephrotoxicity.氨基糖苷类：肾毒性。
Antimicrob Agents Chemother. 1999 May;43(5):1003-12. doi: 10.1128/AAC.43.5.1003.
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Aminoglycosides: activity and resistance.氨基糖苷类：活性与耐药性。
Antimicrob Agents Chemother. 1999 Apr;43(4):727-37. doi: 10.1128/AAC.43.4.727.
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A cDNA encoding starch branching enzyme I from maize endosperm.一种编码来自玉米胚乳的淀粉分支酶I的cDNA。
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