Frank J, Chafetz L
J Pharm Sci. 1977 Mar;66(3):439. doi: 10.1002/jps.2600660336.
Carbachol ophthalmic solutions can be assayed by evaporating a measured volume, dissolving the residue in methanol, and scanning the carbonyl stretching frequency in an IR spectrophotometer using a cell with calcium fluoride windows. Methylcellulose and other formulation vehicle components do not interfere. The method is stability indicating with respect to hydrolysis. It affords a recovery of 99.5+/-0.51% (RSD).
卡巴胆碱眼用溶液可以通过蒸发一定体积的溶液、将残渣溶解在甲醇中，并使用带有氟化钙窗口的样品池在红外分光光度计中扫描羰基伸缩频率来进行测定。甲基纤维素和其他制剂辅料成分不产生干扰。该方法对于水解具有稳定性指示作用。其回收率为99.5±0.51%（相对标准偏差）。
