Kwok S P, Lau W Y, Leung K L, Ku K W, Ho W S, Li A K
Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.
Chemotherapy. 1993 Mar-Apr;39(2):135-9. doi: 10.1159/000239116.
In a prospective randomised controlled trial, amoxycillin plus clavulanic acid was compared to a combination of cefotaxime and metronidazole as prophylactic antibiotics in 164 patients who underwent elective colorectal resectional surgery. Wound infection occurred in 15 patients (9.1%) and deep surgical infection in 4 (2.4%). Seven cases of wound infection and 2 cases of deep infection occurred in the amoxycillin plus clavulanic acid arm, while 8 cases of wound infection and 2 cases of deep infection occurred in the cefotaxime plus metronidazole arm. Eighty-eight percent of infections occurred in patients who had low anterior resection or abdominoperineal resection of the rectum. Both the amoxycillin plus clavulanic acid and the combination of cefotaxime and metronidazole offer the same degree of protection against post-operative infection. The use of amoxycillin plus clavulanic acid as antibiotic prophylaxis is recommended because of its easier use and cheaper cost.
在一项前瞻性随机对照试验中，将阿莫西林加克拉维酸与头孢噻肟和甲硝唑的组合作为预防性抗生素，用于164例行择期结直肠切除手术的患者。15例（9.1%）发生伤口感染，4例（2.4%）发生深部手术感染。阿莫西林加克拉维酸组发生7例伤口感染和2例深部感染，而头孢噻肟加甲硝唑组发生8例伤口感染和2例深部感染。88%的感染发生在低位前切除术或直肠腹会阴联合切除术的患者中。阿莫西林加克拉维酸和头孢噻肟与甲硝唑的组合对术后感染提供相同程度的保护。由于使用更方便且成本更低，推荐使用阿莫西林加克拉维酸作为抗生素预防用药。
