Friese S, Willems F T, Loriaux S M, Meewis J M
Department of Obstetrics and Gynaecology, Stichting Ignatius Ziekenhuis, Breda, The Netherlands.
J Antimicrob Chemother. 1989 Nov;24 Suppl B:213-6. doi: 10.1093/jac/24.suppl_b.213.
A prospective randomized comparison of a single pre-operative dose of 2.2 g amoxycillin/clavulanate versus the combination of 1.5 g cefuroxime plus 0.5 g metronidazole was conducted in 467 women, who underwent gynaecological surgery. The incidence of febrile morbidity, urinary tract infection, wound infection and the use of post-operative antimicrobial agents was similar in the two groups. Amoxycillin/clavulanate is as effective as a combination of cefuroxime and metronidazole and less expensive.
对467名接受妇科手术的女性进行了一项前瞻性随机对照研究，比较术前单次给予2.2克阿莫西林/克拉维酸盐与1.5克头孢呋辛加0.5克甲硝唑联合用药的效果。两组的发热性疾病、尿路感染、伤口感染发生率以及术后抗菌药物的使用情况相似。阿莫西林/克拉维酸盐与头孢呋辛和甲硝唑联合用药同样有效，且成本更低。
