Periti P, Tonelli F, Mazzei T, Ficari F
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
J Chemother. 1993 Feb;5(1):37-42. doi: 10.1080/1120009x.1993.11739207.
Surgical antimicrobial prophylaxis was performed with a controlled study on 859 evaluable patients randomized into two groups treated with chemoprophylaxis only or chemo- and immunoprophylaxis in colorectal surgery. Immuno and chemoprophylactic treatment (425 patients) consisted of 70 mg i.m. thymostimulin per day for 7 days beginning 48 h before surgery plus 2 g cefotetan at the moment of induction of anesthesia; the other group (434 patients) received only the single dose of antibiotic. Results in the two different groups were significantly different regarding abdominal abscess and the total infectious episodes in the surgical site with lower frequency in patients receiving both thymostimulin and the antibiotic (cefotetan). Moreover the respiratory tract infections were more than double in those patients not treated with perioperative immunotherapy. Stratifying patients on the basis of grade of skin test reaction, we observed a significantly lower percentage of surgical site infection in hypoergic patients receiving chemo- and immunoprophylaxis.
在一项对照研究中，对859例可评估患者进行了手术抗菌预防，这些患者被随机分为两组，一组仅接受化学预防，另一组在结直肠手术中接受化学和免疫预防。免疫和化学预防治疗组（425例患者）在手术前48小时开始每天肌肉注射70毫克胸腺刺激素，持续7天，同时在麻醉诱导时给予2克头孢替坦；另一组（434例患者）仅接受单剂量抗生素治疗。在腹部脓肿和手术部位的总感染发作方面，两组结果有显著差异，接受胸腺刺激素和抗生素（头孢替坦）联合治疗的患者频率较低。此外，未接受围手术期免疫治疗的患者呼吸道感染发生率增加了一倍多。根据皮肤试验反应等级对患者进行分层，我们观察到接受化学和免疫预防的低反应性患者手术部位感染的百分比显著降低。
