Samukawa T
Department of Otolaryngology, Wakayama Medical College.
Nihon Jibiinkoka Gakkai Kaiho. 1993 Jan;96(1):88-97. doi: 10.3950/jibiinkoka.96.88.
We investigated the expression of HLA-DR antigen on 42 squamous cell carcinomas of head and neck using immunohistological methods. Our results indicate significant relationships between HLA-DR antigen expression on carcinomas and lymphocytic infiltration, that is, CD8 positive lymphocytes (CD8/CD3) infiltrated HLA-DR antigen positive carcinomas while CD4 positive cells (CD4/CD3) were found in HLA-DR negative carcinoma. The Ki-67 (a nuclear marker of proliferation) positive rate was lower on HLA-DR positive carcinomas than on negative carcinomas. However, there was no correlation with pathological differentiation, clinical stage or primary lesion. In vitro studies using several cytokines showed that IFN-gamma induced expression of HLA-DR antigen and lowered the Ki-67 positive rate on squamous cell carcinomas. It seems that HLA-DR antigen expression on squamous cell carcinomas could be induced by cytokines released from the infiltrating lymphocytes.
我们采用免疫组织学方法研究了42例头颈部鳞状细胞癌中HLA-DR抗原的表达情况。我们的结果表明，癌组织中HLA-DR抗原表达与淋巴细胞浸润之间存在显著相关性，即CD8阳性淋巴细胞（CD8/CD3）浸润HLA-DR抗原阳性的癌组织，而CD4阳性细胞（CD4/CD3）则见于HLA-DR阴性的癌组织。HLA-DR阳性癌组织的Ki-67（增殖的核标志物）阳性率低于阴性癌组织。然而，其与病理分化、临床分期或原发灶均无相关性。使用多种细胞因子的体外研究表明，IFN-γ可诱导HLA-DR抗原表达并降低鳞状细胞癌的Ki-67阳性率。似乎鳞状细胞癌上的HLA-DR抗原表达可由浸润淋巴细胞释放的细胞因子诱导产生。
