Korsch E, Gillor A, Groneck P, Bläker F
Kinderkrankenhaus der Stadt Köln.
Monatsschr Kinderheilkd. 1993 Feb;141(2):112-5.
There is an increasing number of reports about the use of dexamethasone in the treatment of preterm infants at high risk for bronchopulmonary dysplasia. The possibility of myocardial hypertrophy developing during this treatment has not been examined.
As an example the course of one patient is described. We examined seven preterm infants (mean birth weight 791 g, mean gestational age 26 weeks) with eight treatments of dexamethasone retrospectively. The therapy was associated with a significant increase of the mean thickness of the interventricular septum and of the left ventricular posterior wall. After the termination of dexamethasone therapy the abnormal echocardiographic findings disappeared.
We suggest careful monitoring of preterm infants treated with dexamethasone by performing serial echocardiographic investigations.
关于地塞米松用于治疗支气管肺发育不良高危早产儿的报道日益增多。但尚未研究在此治疗过程中发生心肌肥厚的可能性。
以一名患者的病程为例进行描述。我们回顾性研究了7例早产儿（平均出生体重791克，平均胎龄26周），他们接受了8次地塞米松治疗。该治疗与室间隔平均厚度和左心室后壁平均厚度显著增加有关。地塞米松治疗结束后，异常的超声心动图表现消失。
我们建议通过进行系列超声心动图检查，对地塞米松治疗的早产儿进行仔细监测。
