接受持续性非卧床腹膜透析的慢性肾衰竭患者的D-乳酸代谢

D-lactate metabolism in patients with chronic renal failure undergoing CAPD.

作者信息

Yasuda T, Ozawa S, Shiba C, Maeba T, Kanazawa T, Sugiyama M, Owada S, Ishida M

机构信息

First Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

出版信息

Nephron. 1993;63(4):416-22. doi: 10.1159/000187245.

DOI:10.1159/000187245

PMID:8459877

Abstract

To clarify the D-lactate metabolism in patients with chronic renal failure undergoing CAPD, plasma levels, loaded doses and urinary excretion of D-lactate were measured. In addition, D-2-hydroxy acid dehydrogenase activities in resected and autopsied specimens were measured. The daily loaded dose of D-lactate by CAPD was 88.9 +/- 1.29 mmol and urinary excretion was negligible. There was no tendency for the plasma D-lactate to accumulate. The enzyme activity was detected in the liver, kidney and pancreas tissues both in the resected and autopsied specimens. The above findings indicate that the loaded D-lactate is catabolized in patients with chronic renal failure undergoing CAPD, and D-2-hydroxy acid dehydrogenase is responsible for the metabolism of D-lactate in humans.

摘要

为阐明接受持续性非卧床腹膜透析（CAPD）的慢性肾衰竭患者体内D-乳酸的代谢情况，我们检测了其血浆中D-乳酸水平、负荷剂量及尿排泄量。此外，还测定了切除标本和尸检标本中D-2-羟酸脱氢酶的活性。CAPD患者每日D-乳酸负荷剂量为88.9±1.29 mmol，尿排泄量可忽略不计。血浆D-乳酸没有蓄积的趋势。在切除标本和尸检标本的肝脏、肾脏和胰腺组织中均检测到了该酶的活性。上述结果表明，接受CAPD的慢性肾衰竭患者体内负荷的D-乳酸可被分解代谢，且D-2-羟酸脱氢酶负责人体内D-乳酸的代谢。