前列腺素对单侧肾切除患者肾功能的影响。
Effect of prostaglandins on renal function in uninephrectomized humans.
作者信息
Mizuiri S, Takano M, Hayashi I, Aikawa A, Ohara T, Hasegawa A
机构信息
Department of Nephrology, Toho University School of Medicine, Tokyo, Japan.
出版信息
Nephron. 1993;63(4):429-33. doi: 10.1159/000187247.
We examined the effects of unilateral nephrectomy (UN) and administration of indomethacin in 15 healthy humans. Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), urine flow, sodium and potassium excretions, urinary excretion rate of prostaglandin E2 (PGE2) and 6-keto prostaglandin F1 alpha (6-keto PGF1 alpha) in the remaining kidney were all significantly (p < 0.01) increased 10 days after UN. Indomethacin administered at 75 mg/day for 3 days abolished the increase in GFR, ERPF and sodium excretion with reduced urinary excretion rate of PGE2 and 6-keto PGF1 alpha but not the increase in urine flow and potassium excretion. These findings suggest that renal prostaglandins may play a role in renal functional adaptation following UN.
我们研究了单侧肾切除（UN）及吲哚美辛给药对15名健康人的影响。单侧肾切除10天后，剩余肾脏的肾小球滤过率（GFR）、有效肾血浆流量（ERPF）、尿流量、钠和钾排泄、前列腺素E2（PGE2）及6-酮前列腺素F1α（6-酮PGF1α）的尿排泄率均显著（p<0.01）升高。以75mg/天的剂量给予吲哚美辛3天，可消除GFR、ERPF及钠排泄的升高，同时降低PGE2和6-酮PGF1α的尿排泄率，但不能消除尿流量和钾排泄的升高。这些发现表明，肾脏前列腺素可能在单侧肾切除后的肾功能适应中发挥作用。
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