Altunkova I, Minkova V, Belovezhdov N
Department of Internal Medicine, Medical Academy, Sofia, Bulgaria.
Nephron. 1993;63(4):438-44. doi: 10.1159/000187249.
There is already a considerable amount of evidence suggesting that fibronectin (Fn) plays an important role in the pathogenic process in some forms of glomerulonephritis (GN). It has been postulated that Fn may participate in the progression or regression of glomerular diseases. The Fn is presented in the kidney as a normal component of the mesangium, and it is increased in the expanded mesangium in various forms of GN. This paper reports our efforts to investigate the role of Fn in plasma and kidney in patients with GN. Using monoclonal antibodies against human Fn in the ELISA and immunohistoperoxidase techniques to evaluate Fn, we investigated its quantity in connection with clinical state and morphological findings. We studied 93 patients with GN and 26 renal biopsies. The patients with active forms of mesangial proliferative, membranoproliferative and membranous GN showed increased plasma Fn, and the highest levels were in patients with nephrotic syndrome. Increased tissue Fn correlated with mesangial expansion and with IgG and C3 deposits. We speculate on possible mechanisms of the involvement of Fn in human chronic GN.
已有大量证据表明，纤维连接蛋白（Fn）在某些形式的肾小球肾炎（GN）的致病过程中起重要作用。据推测，Fn可能参与肾小球疾病的进展或消退。Fn在肾脏中作为系膜的正常成分存在，并且在各种形式的GN中扩张的系膜中增加。本文报告了我们对GN患者血浆和肾脏中Fn作用的研究。我们使用ELISA和免疫组化技术中的抗人Fn单克隆抗体来评估Fn，并研究其数量与临床状态和形态学发现的关系。我们研究了93例GN患者和26例肾活检病例。系膜增生性、膜增生性和膜性GN的活动形式患者血浆Fn升高，肾病综合征患者的水平最高。组织Fn增加与系膜扩张以及IgG和C3沉积相关。我们推测了Fn参与人类慢性GN的可能机制。
