Klonoff-Cohen H, Edelstein S, Savitz D
Division of Epidemiology, Community and Family Medicine, University of California, San Diego, La Jolla.
Obstet Gynecol. 1993 Apr;81(4):541-4.
To examine the relationship between cigarette smoking during pregnancy and the development of preeclampsia.
A case-control study compared the smoking histories of 110 nulliparous preeclamptic women and 115 healthy nulliparas aged 15-35 years who delivered at North Carolina Memorial Hospital.
Unconditioned logistic regression relating smoking during pregnancy to preeclampsia yielded an odds ratio of 0.71 (95% confidence interval 0.33-1.50) when adjusting for working during pregnancy, alcohol use, medication use, contraceptive choices with the father of the index pregnancy, and family history of preeclampsia. There was no evidence of a dose-response effect of reduced risk for heavier smokers.
Despite major methodologic improvements from previous studies, including rigorous diagnostic criteria for preeclampsia, a negative, non-statistically significant association persisted between cigarette smoking during pregnancy and preeclampsia, similar in magnitude to that of previous reports.
研究孕期吸烟与子痫前期发生发展之间的关系。
一项病例对照研究比较了在北卡罗来纳大学纪念医院分娩的110例初产子痫前期妇女和115例年龄在15 - 35岁的健康初产妇的吸烟史。
在对孕期工作、饮酒、用药、与本次妊娠胎儿父亲的避孕选择以及子痫前期家族史进行校正后，将孕期吸烟与子痫前期进行非条件逻辑回归分析，得出比值比为0.71（95%置信区间0.33 - 1.50）。没有证据表明重度吸烟者降低风险存在剂量反应效应。
尽管与之前的研究相比在方法学上有了重大改进，包括子痫前期严格的诊断标准，但孕期吸烟与子痫前期之间仍存在负性、无统计学意义的关联，其强度与之前的报告相似。
