Dalinghaus M, Gratama J W, Koers J H, Gerding A M, Meuzelaar K J, van de Berg M, Zijlstra W G, Kuipers J R
Beatrix Children's Hospital, Groningen, The Netherlands.
Pediatr Res. 1993 Mar;33(3):267-72. doi: 10.1203/00006450-199303000-00012.
Chronic hypoxemia is associated with a decreased growth rate and a decreased rate of cell division. In lambs with experimental cyanotic heart disease, the gain in body mass was decreased. In this study, we determined to what extent the lower body mass in these lambs was related to alterations in body fluid compartment volumes, specifically whether intracellular volume was decreased. Therefore, fluid compartment volumes were studied in nine lambs, after 3 to 4 wk of experimental cyanotic heart disease, and in 13 control lambs. Hypoxemic lambs had a lower arterial oxygen saturation (65 +/- 11 versus 91 +/- 2%, p < 0.001) and a higher Hb concentration (142 +/- 16 versus 101 +/- 8 g.L-1, p < 0.001). The lower body mass in hypoxemic lambs (10.5 +/- 2.3 versus 13.0 +/- 2.8 kg) could be mainly accounted for by a decrease in intracellular water volume (4.7 +/- 1.3 versus 6.6 +/- 1.5 L, p < 0.01). Total body water (753 +/- 27 versus 780 +/- 40 mL.kg-1) and extracellular water volume (307 +/- 25 versus 277 +/- 15 mL.kg-1) in hypoxemic lambs were not significantly different from those in control lambs, but intracellular water volume was decreased (445 +/- 27 versus 501 +/- 35 mL.kg-1, p < 0.01). The ratio of extracellular to intracellular water volume was higher in hypoxemic lambs (0.69 +/- 0.10 versus 0.55 +/- 0.04, p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
慢性低氧血症与生长速率降低和细胞分裂速率降低有关。在患有实验性紫绀型心脏病的羔羊中，体重增加减少。在本研究中，我们确定这些羔羊较低的体重在多大程度上与体液腔室体积的改变有关，特别是细胞内体积是否减少。因此，对9只患有3至4周实验性紫绀型心脏病的羔羊和13只对照羔羊的体液腔室体积进行了研究。低氧血症羔羊的动脉血氧饱和度较低（65±11% 对 91±2%，p<0.001）且血红蛋白浓度较高（142±16对101±8 g.L-1，p<0.001）。低氧血症羔羊较低的体重（10.5±2.3对13.0±2.8 kg）主要是由于细胞内水量减少（4.7±1.3对6.6±1.5 L，p<0.01）。低氧血症羔羊的总体水（753±27对780±40 mL.kg-1）和细胞外水量（307±25对277±15 mL.kg-1）与对照羔羊相比无显著差异，但细胞内水量减少（445±27对501±35 mL.kg-1，p<0.01）。低氧血症羔羊的细胞外与细胞内水量之比更高（0.69±0.10对0.55±0.04，p<0.01）。（摘要截断于250字）
