Madison J B, Ziemer E L
Department of Clinical Studies, New Bolton Center, Kennett Square, Pennsylvania 19348.
Res Vet Sci. 1993 Mar;54(2):256-8. doi: 10.1016/0034-5288(93)90068-q.
Purified streptococcal M protein was injected into one intercarpal joint in three horses hyperimmunised with Streptococcus equi M protein vaccine. The contralateral joints were injected with pH adjusted polyionic solution. All antigen-injected joints developed a severe suppurative synovitis (mean synovial fluid nucleated cell count = 102,200 x 10(6) cells litre-1). Eosinophils were found in the synovial fluid and in synovial membrane biopsy specimens of two of the horses. Immune complexes were not demonstrated in the synovial membrane. Two horses are described that developed synovial fluid eosinophilia after the intra-articular injection of streptococcal antigen.
将纯化的链球菌M蛋白注射到3匹用马链球菌M蛋白疫苗进行过超免疫的马的一个腕骨间关节中。对侧关节注射经pH调节的聚离子溶液。所有注射抗原的关节均出现严重的化脓性滑膜炎（滑膜液有核细胞计数平均值 = 102,200×10⁶个/升）。在其中两匹马的滑膜液和滑膜活检标本中发现了嗜酸性粒细胞。滑膜中未证实有免疫复合物。描述了两匹马在关节内注射链球菌抗原后出现滑膜液嗜酸性粒细胞增多的情况。
