Ishii Y, Itoh H, Hara A, Mukai T, Yokota M
Jpn Circ J. 1977 Feb;41(2):117-27. doi: 10.1253/jcj.41.117.
Utilizing 133-xenon gas and a scintillation camera, we examined the distributional relation between ventillation (V) and perfusion (Q) in patients with pulmonary hypertension (PH) comprising mitral stenosis (MS) and left to right shunt disease (shunt). In the case of MS, Q decreased at the dependent part of lung in proportion to the degree of PH, but preserved normal V and resulted in high V/Q value at this region, which was estimated to cause and physiological dead space effect on the gas exchange function. In the case of shunt disease, even with a high degree of PH, reduction of Q at the dependent lung region was not observed with normal preservation of V, thus obviating any type of the V/Q imbalance. Since the washout of xenon gas by resting tidal volume ventilation was observed to be delayed from the dependent lung region, latent ventilatory impairment in this region due to small airway closure at tidal breathing was also suspected.
利用133氙气和闪烁照相机，我们研究了包括二尖瓣狭窄（MS）和左向右分流疾病（分流）的肺动脉高压（PH）患者通气（V）与灌注（Q）之间的分布关系。在MS病例中，肺下垂部位的Q随着PH程度的增加而降低，但V保持正常，导致该区域V/Q值升高，估计这会对气体交换功能产生生理性死腔效应。在分流疾病病例中，即使PH程度较高，肺下垂部位的Q也没有降低，V保持正常，从而避免了任何类型的V/Q失衡。由于观察到静息潮气量通气时氙气从肺下垂部位的清除延迟，因此怀疑该区域在潮式呼吸时因小气道关闭而存在潜在的通气功能损害。
