Gehrig W, Meyer P, Ising H, Kuhl K D, Schmidt R, Grützmacher W
Schriftenr Ver Wasser Boden Lufthyg. 1993;88:368-78.
The auditory thresholds of about 60 anaesthetized guinea pigs were determined at 3 or 4 frequencies between 2 and 20 kHz using the acoustically evoked brain stem potentials. The animals were then exposed to electro-acoustically reproduced MLAF noise with peak levels between 120 and 130 dB(A). The exposure occurred either once or else four times within either 3 or 60 minutes. The level of noise increased at 7.5 and 75 dB/s (slow and fast increase). TTS was then determined. PTS was measured one week later. In over half the animals, exposure to rapidly increasing noise level with a peak of 126 dB(A) induced PTS > or = 30 dB for at least one frequency. Exposure to a slowly increasing noise level with the same peak provoked significantly smaller PTS. 4 exposures to a rapidly rising noise level within 3 minutes induced significantly smaller PTS than the same dosage within 60 minutes. Only in the latter case was PTS greater than TTS.
使用听觉诱发脑干电位,在2至20千赫兹之间的3或4个频率下测定了约60只麻醉豚鼠的听觉阈值。然后让这些动物暴露于电声再现的MLAF噪声中,峰值水平在120至130分贝(A)之间。暴露发生一次,或者在3或60分钟内进行四次。噪声水平以7.5和75分贝/秒的速度增加(缓慢增加和快速增加)。然后测定暂时性阈移(TTS)。一周后测量永久性阈移(PTS)。在超过一半的动物中,暴露于峰值为126分贝(A)的快速增加的噪声水平下,至少一个频率的永久性阈移≥30分贝。暴露于峰值相同的缓慢增加的噪声水平下,永久性阈移明显较小。在3分钟内4次暴露于快速上升的噪声水平下引起的永久性阈移明显小于在60分钟内相同剂量引起的永久性阈移。只有在后一种情况下,永久性阈移才大于暂时性阈移。