Lopez-Beltran A, Croghan G A, Croghan I, Gaeta J F
Unit of Anatomical Pathology, Cordoba University Medical School, Spain.
Urol Int. 1993;50(2):61-4. doi: 10.1159/000282453.
A wide range of cell and tumor markers including the blood group-related isoantigens A, B, O(H) and T-Ag, the cell markers DCA(F36/22) and epithelial membrane antigen (EMA), and the oncogene-related proteins RAP-5p21 and ORP-p21 were investigated by means of immunohistochemistry in selected biopsies from 36 bladder cancer patients with the aim of ascertaining which are of value in patients' survival. A heterogeneous distribution of positivity was found for each marker. In addition, EMA immunostaining correlated significantly (p < 0.05) with patient survival. We conclude that immunohistochemical detection of EMA may provide additional prognostic information in bladder cancer patients.
通过免疫组织化学方法，对36例膀胱癌患者的选定活检样本进行了研究，检测了多种细胞和肿瘤标志物，包括血型相关的同种抗原A、B、O(H)和T抗原、细胞标志物DCA(F36/22)和上皮膜抗原(EMA)，以及癌基因相关蛋白RAP-5p21和ORP-p21，目的是确定哪些标志物对患者的生存有价值。结果发现，每种标志物的阳性分布均不相同。此外，EMA免疫染色与患者生存率显著相关(p < 0.05)。我们得出结论，EMA的免疫组化检测可能为膀胱癌患者提供额外的预后信息。
