Gennuso R, Spigelman M K, Chinol M, Zappulla R A, Nieves J, Vallabhajosula S, Alberto Paciucci P, Goldsmith S J, Holland J F
Division of Neurosurgery, New Jersey's Neuroscience Institute, JFK Medical Center, New York, New York.
Cancer Invest. 1993;11(2):118-28. doi: 10.3109/07357909309024829.
In this study of 25 central nervous system (CNS) tumor-bearing rats, the CNS biodistribution of intravenously administered, indium-labeled liposomes was investigated. In 16 animals, the blood-brain barrier and blood-tumor barrier were modified using intracarotid administration of etoposide. In control animals, analysis by autoradiography and well-counting experiments demonstrated uptake of liposomes in the tumor-bearing hemisphere (% injected dose/g tissue = 0.135) with minimal uptake in the non-tumor-bearing hemisphere (% injected dose/g tissue = 0.007), p < 0.01. Unilateral intracarotid etoposide administration enhanced liposome uptake in both hemispheres-0.215 and 0.023 (tumor-bearing and nontumor-bearing), respectively. The presence of meningeal tumor involvement in nontumor-implanted hemispheres increased liposomal uptake 10-fold. These findings may have clinical applicability in designing therapeutic protocols for the treatment of CNS tumors.
在这项对25只患有中枢神经系统（CNS）肿瘤的大鼠的研究中，研究了静脉注射铟标记脂质体在中枢神经系统的生物分布。在16只动物中，通过颈内动脉给予依托泊苷来改变血脑屏障和血肿瘤屏障。在对照动物中，通过放射自显影分析和计数实验表明，在荷瘤半球脂质体有摄取（每克组织注射剂量百分比=0.135），而在非荷瘤半球摄取极少（每克组织注射剂量百分比=0.007），p<0.01。单侧颈内动脉给予依托泊苷增强了脂质体在两个半球的摄取，分别为0.215和0.023（荷瘤和非荷瘤）。在未植入肿瘤的半球中存在脑膜肿瘤浸润会使脂质体摄取增加10倍。这些发现可能在设计中枢神经系统肿瘤治疗方案方面具有临床应用价值。
