Hausen B M
Department of Dermatology, University Hospital, Hamburg, Germany.
Contact Dermatitis. 1993 Mar;28(3):149-53. doi: 10.1111/j.1600-0536.1993.tb03376.x.
Using a modified FCA (Freund's complete adjuvant) procedure, the sensitizing capacity of Euxyl K 400 and its ingredients, 1,2-dibromo-2,4-dicyanobutane and 2-phenoxyethanol, has been studied in guinea pigs. The experiments demonstrate that a distinct but weak sensitizing potency exists for Euxyl K 400 and dibromodicyanobutane. Phenoxyethanol remained almost negative. These results are in good accordance with the low number of cases of allergic contact dermatitis due to Euxyl K 400 and dibromodicyanobutane described since their introduction on the market. Cases of phenoxyethanol contact allergy have been published hitherto only 4x in the medical literature.
采用改良的弗氏完全佐剂（FCA）方法，在豚鼠身上研究了优乐散K 400及其成分1,2 - 二溴 - 2,4 - 二氰基丁烷和2 - 苯氧基乙醇的致敏能力。实验表明，优乐散K 400和二溴二氰基丁烷存在明显但较弱的致敏效力。苯氧基乙醇几乎呈阴性反应。这些结果与自优乐散K 400和二溴二氰基丁烷上市以来所报道的因它们引起的过敏性接触性皮炎病例数量较少的情况高度相符。迄今为止，医学文献中仅4次报道了苯氧基乙醇接触过敏的病例。
