The risk perceptions and self-protective behavior of 282 immigrant farm workers (all of Mexican origin) in response to pesticide exposure were examined. Several variables were predicted to influence reactions, but some deviations from past studies were expected because cultural or socioeconomic factors could modify risk responses. In keeping with predictions, greater risk perceptions were associated with beliefs that past harm had occurred, future harm to self or offspring was likely, precautions were less effective, and cancer-causing agents were mostly unavoidable. Self-protective behavior was most likely for those receiving risk information, having greater perceptions of control over health and the occupational situation, and believing that precautionary methods were effective. The discussion considers variability in responses to chronic risk and the broader perspective offered by environmental hazard studies.