环丁砜作为新型高亲和力P2配体用于HIV-1蛋白酶抑制剂 - Suppr

Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.

作者信息

Ghosh A K, Thompson W J, Lee H Y, McKee S P, Munson P M, Duong T T, Darke P L, Zugay J A, Emini E A, Schleif W A

机构信息

Department of Medicinal Chemistry, Molecular Biology, and Virus and Cell Biology, Merck Research Laboratories, West Point, Pennsylvania 19486.

出版信息

J Med Chem. 1993 Apr 2;36(7):924-7. doi: 10.1021/jm00059a019.

DOI:10.1021/jm00059a019

PMID:8464047

Abstract

摘要

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Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.环丁砜作为新型高亲和力P2配体用于HIV-1蛋白酶抑制剂

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An old target revisited: two new privileged skeletons and an unexpected binding mode for HIV-protease inhibitors.一个重新审视的旧靶点：两种新型优势骨架及HIV蛋白酶抑制剂一种意外的结合模式

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Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands.发现具有皮摩尔亲和力的HIV-1蛋白酶抑制剂，其包含N-芳基-恶唑烷酮-5-甲酰胺作为新型P2配体。

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Design, biologic evaluation, and SAR of novel pseudo-peptide incorporating benzheterocycles as HIV-1 protease inhibitors.新型含苯并杂环的拟肽 HIV-1 蛋白酶抑制剂的设计、生物学评价及构效关系研究。

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Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.

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