Layer P, Gröger G, Grandt D, Cherian L
Abteilung für Gastroenterologie, Universität (GHS) Essen.
Med Klin (Munich). 1993 Feb 15;88 Suppl 1:15-7.
Nutrients present in the ileum of humans can modulate endogenously stimulated pancreatic secretion. To determine whether cyclic interdigestive pancreatic secretion can also be influenced by nutrients in the ileum, six fasting volunteers were intubated with an oro-ileal multi-lumen tube for perfusing test and marker solutions, aspiration of duodenal contents and recording of motility. At the beginning of the interdigestive cycle, the ileum was perfused intermittently with solutions of carbohydrates, proteins or lipids in the physiological amounts observed in the ileum after a meal; saline solution was perfused as a control. After saline, protein and calcium perfusion, the expected periodic increase in chymotrypsin secretion was observed during phase II of the interdigestive cycle (p < 0.05 vs phase I). In contrast, carbohydrates and lipids inhibited the phase-II-associated increase in pancreatic secretion. These findings indicate that the ileum may be involved in the regulation of human interdigestive pancreatic secretion.
人体回肠中的营养物质可调节内源性刺激的胰腺分泌。为了确定回肠中的营养物质是否也能影响周期性消化间期胰腺分泌，六名空腹志愿者经口插入回肠多腔管，用于灌注测试溶液和标记溶液、抽吸十二指肠内容物以及记录胃肠蠕动。在消化间期开始时，向回肠间歇性灌注碳水化合物、蛋白质或脂质溶液，其剂量为餐后回肠中观察到的生理剂量；灌注生理盐水作为对照。灌注生理盐水、蛋白质和钙后，在消化间期II期观察到预期的胰凝乳蛋白酶分泌周期性增加（与I期相比，p < 0.05）。相比之下，碳水化合物和脂质抑制了与II期相关的胰腺分泌增加。这些发现表明，回肠可能参与了人体消化间期胰腺分泌的调节。
