Smith V V
Department of Histopathology, Hospitals for Sick Children, London, UK.
Pediatr Pathol. 1993 Mar-Apr;13(2):225-37. doi: 10.3109/15513819309048209.
In the absence of reliable baseline data for normal neuron density in the intestine, the diagnosis of hypo- and hyperganglionosis is purely subjective. This study has established the normal neuron density by neuron counts in paraffin sections taken both transversely (transverse sections, TS) and longitudinally (longitudinally sections, LS) in relation to the long axis of normal postmortem jejunum, ileum, and colon from 21 children (aged 4 weeks to 10 years). Intestine from two adults (aged 16 and 42 years) and colon alone from a further six adults (aged 16 to 83 years) were also studied. The mean density values in childhood were for jejunum 3.6/mm (TS), 3.7/mm (LS); for ileum 4.3/mm (TS, LS); and for colon 7/mm (LS), 7.7/mm (TS). The proximal margins of surgically resected colons from six patients with Hirschsprung's disease and one patient with suspected isolated hypoganglionosis were also analyzed and the neuron densities compared with the established postmortem data. Neuron density values outside two standard deviations from the postmortem mean were shown to correlate with continuing pseudo-obstructive symptoms in these patients.
由于缺乏关于肠道正常神经元密度的可靠基线数据，低神经节症和高神经节症的诊断完全是主观的。本研究通过对21名儿童（4周龄至10岁）正常尸检空肠、回肠和结肠长轴的横向（横切面，TS）和纵向（纵切面，LS）石蜡切片中的神经元进行计数，确定了正常神经元密度。还研究了两名成年人（16岁和42岁）的肠道以及另外六名成年人（16岁至83岁）单独的结肠。儿童时期的平均密度值为：空肠横切面3.6/mm，纵切面3.7/mm；回肠横切面和纵切面均为4.3/mm；结肠纵切面7/mm，横切面7.7/mm。还分析了6例先天性巨结肠患者和1例疑似孤立性低神经节症患者手术切除结肠的近端边缘，并将神经元密度与已建立的尸检数据进行比较。结果显示，这些患者中神经元密度值超出尸检平均值两个标准差与持续的假性梗阻症状相关。
