Zemon V, Pinkhasov E, Gordon J
Laboratory of Biophysics, Rockefeller University, New York, NY 10021-6399.
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2975-8. doi: 10.1073/pnas.90.7.2975.
Evoked cortical potentials were used to test neural models of binocular interactions in humans. The critical feature that distinguished between basic models was whether the two monocular signals combined linearly or nonlinearly. Stimuli were presented separately and simultaneously to two eyes with the relative temporal phase parametrically varied. Fourier analysis was applied to the recorded electroencephalogram to measure the frequency response of the visual cortex to this stimulation. Comparisons of the models' predictions with the experimental results indicate that the greatest contribution to the cortical response originates in a neural pathway that contains nonlinear binocular combination, and a smaller contribution originates in a pathway with linear binocular combination. Current models, based on psychophysical studies of humans and on single-cell neurophysiological investigations of cats, are inadequate to explain these results. A model of binocular interaction is proposed that does account for the present findings and is also supported by neurophysiological studies on monkeys. This model, which contains both nonlinear and linear binocular interactions, has profound implications for perceptual processing.
诱发皮层电位被用于测试人类双眼相互作用的神经模型。区分基本模型的关键特征是两个单眼信号是线性组合还是非线性组合。刺激分别和同时呈现给两只眼睛，相对时间相位参数可变。对记录的脑电图进行傅里叶分析，以测量视觉皮层对这种刺激的频率响应。模型预测与实验结果的比较表明，对皮层反应的最大贡献源自包含非线性双眼组合的神经通路，而较小的贡献源自具有线性双眼组合的通路。基于对人类的心理物理学研究和对猫的单细胞神经生理学研究的现有模型，不足以解释这些结果。提出了一个双眼相互作用模型，该模型确实解释了目前的发现，并且也得到了对猴子的神经生理学研究的支持。这个包含非线性和线性双眼相互作用的模型，对知觉加工具有深远的意义。
