胆囊癌中银结合嗜银核仁组织区（AgNOR）：与恶性分级和预后的相关性

Silver-binding argyrophilic nucleolar organizer regions (AgNOR) in gall-bladder cancer: correlations with malignant grading and prognosis.

作者信息

Suzuki T, Takano Y, Kida Y, Okudaira M

机构信息

Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.

出版信息

Acta Pathol Jpn. 1993 Jan-Feb;43(1-2):36-43. doi: 10.1111/j.1440-1827.1993.tb02912.x.

DOI:10.1111/j.1440-1827.1993.tb02912.x

PMID:8465655

Abstract

Silver-binding nucleolar organizer regions (AgNOR) were investigated and compared in 43 cases of gall-bladder cancers and 10 normal gall-bladder samples using an image analyzer. The mean numbers of AgNOR per nucleus (AgNOR number) were 3.28 +/- 1.38 in the gall-bladder cancers and 1.86 +/- 0.20 in the normal gall-bladder cases. The respective mean areas of AgNOR per nucleus (AgNOR area) were 6.96 +/- 3.78 microns2 and 1.89 +/- 0.21 microns2. The differences were statistically significant (P < 0.0001) for both parameters. In addition, increased frequency and enlargement were both apparently correlated with poor prognosis (P < 0.011 and P < 0.046, respectively), with AgNOR number and AgNOR area showing tendencies for increase in cases of histologically high grade malignancy, advanced cancer and regional lymph node involvement. In conclusion, AgNOR number and AgNOR area appear to be useful indicators for the grading of malignancies and for the prediction of gall-bladder cancer prognosis.

摘要

使用图像分析仪对43例胆囊癌病例和10份正常胆囊样本中的银结合核仁组织区（AgNOR）进行了研究和比较。胆囊癌中每个细胞核的AgNOR平均数（AgNOR数）为3.28±1.38，正常胆囊病例中为1.86±0.20。每个细胞核的AgNOR平均面积（AgNOR面积）分别为6.96±3.78平方微米和1.89±0.21平方微米。这两个参数的差异均具有统计学意义（P<0.0001）。此外，频率增加和面积增大均与预后不良明显相关（分别为P<0.011和P<0.046），在组织学高级别恶性肿瘤、晚期癌症和区域淋巴结受累的病例中，AgNOR数和AgNOR面积均有增加趋势。总之，AgNOR数和AgNOR面积似乎是恶性肿瘤分级和胆囊癌预后预测的有用指标。