Jezernik K, Pipan N
Institute of Cell Biology, Medical Faculty, Ljubljana, Slovenia.
Anat Rec. 1993 Apr;235(4):533-8. doi: 10.1002/ar.1092350405.
Formation of the blood-urine permeability barrier in differentiating mouse transitional urothelium was studied. It was established that the development of superficial cell barrier is a two-phase process: beginning with formation of the tight junctions, followed by formation of fusiform vesicles and asymmetric apical plasma membranes. Fusiform vesicles differentiate during days 15 and 17 of gestation and fuse with the apical plasmalemma. Thus a thick membrane is formed before the excretion of hypertonic urine into the embryonic bladder. Through some degenerative superficial cells slough between fetal day 17 and the day of birth, the bladder epithelium in mice does not lack an effective permeability barrier.
研究了分化中的小鼠移行性尿路上皮血-尿渗透屏障的形成。结果表明，表层细胞屏障的发育是一个两阶段过程：始于紧密连接的形成，随后是梭形小泡和不对称顶端质膜的形成。梭形小泡在妊娠第15天和第17天分化，并与顶端质膜融合。因此，在高渗尿液排入胚胎膀胱之前形成了一层厚膜。在胎儿第17天到出生日之间，一些退化的表层细胞脱落，但小鼠膀胱上皮并不缺乏有效的渗透屏障。
