Jezernik K
Institute of Cell Biology, Medical Faculty, Ljubljana, Slovenia.
Pflugers Arch. 1996;431(6 Suppl 2):R249-50. doi: 10.1007/BF02346362.
Desquamation of urothelial cells is brought about by various specific inductions. Moderate stress in mouse female adults induced by constant illumination for 96 hours results in desquamation of superficial and intermediate cells. Application of endotoxin LPS involves desquamation of single cells as well as whole sheets of cells from the underlying lamina propria. Cell detachment involves interruption of tight junctions between neighbouring cells, reorganisation of intermediate filaments and concentration of different vacuoles or multivesicular bodies. These results clearly demonstrate the involvement of specific adhesion mechanisms during detachment and desquamation of uroepithelial cells.
尿路上皮细胞的脱落是由多种特定诱导因素引起的。对成年雌性小鼠持续光照96小时所诱导的适度应激会导致表层和中层细胞脱落。应用内毒素脂多糖会导致单个细胞以及来自下层固有层的整片细胞脱落。细胞脱离涉及相邻细胞间紧密连接的中断、中间丝的重新组织以及不同液泡或多囊泡体的聚集。这些结果清楚地表明了在尿路上皮细胞脱离和脱落过程中特定黏附机制的参与。
