Weir P M, Munro H M, Reynolds P I, Lewis I H, Wilton N C
Section of Pediatric Anesthesiology, C.S. Mott Childrens Hospital, University of Michigan, Ann Arbor 48109.
Anesth Analg. 1993 Apr;76(4):760-4. doi: 10.1213/00000539-199304000-00013.
A prospective, randomized, double-blind study was conducted to examine the effect of a propofol infusion on the incidence of postoperative emesis in children undergoing outpatient strabismus surgery. Seventy-eight children, aged 3-12 yr, were allocated randomly to receive either nitrous oxide and halothane or nitrous oxide and a propofol infusion for the maintenance of anesthesia. The overall incidence of vomiting during the first 24 h was 64% in those receiving halothane and 41% in those receiving the propofol infusion; this difference was statistically significant (P < 0.05). In children who received no opioids postoperatively, the incidence of vomiting in the first 24 h was 71% in the halothane group and 24% in the propofol group; this difference was also significant (P = 0.001). We conclude that propofol was effective in reducing the incidence of postoperative emesis in pediatric outpatient strabismus surgery.
进行了一项前瞻性、随机、双盲研究，以检验丙泊酚输注对接受门诊斜视手术儿童术后呕吐发生率的影响。78名3至12岁的儿童被随机分配，分别接受氧化亚氮和氟烷或氧化亚氮和丙泊酚输注以维持麻醉。接受氟烷的患儿在前24小时内呕吐的总发生率为64%，接受丙泊酚输注的患儿为41%；这一差异具有统计学意义（P < 0.05）。在术后未使用阿片类药物的儿童中，氟烷组在前24小时内呕吐的发生率为71%，丙泊酚组为24%；这一差异也具有显著性（P = 0.001）。我们得出结论，丙泊酚在降低小儿门诊斜视手术术后呕吐发生率方面是有效的。
