34种载脂蛋白(a)异构体的鉴定：美国黑人和白人之间载脂蛋白(a)等位基因的差异表达。
Identification of 34 apolipoprotein(a) isoforms: differential expression of apolipoprotein(a) alleles between American blacks and whites.
作者信息
Marcovina S M, Zhang Z H, Gaur V P, Albers J J
机构信息
Department of Medicine, Northwest Lipid Research Laboratories, University of Washington, Seattle, WA.
出版信息
Biochem Biophys Res Commun. 1993 Mar 31;191(3):1192-6. doi: 10.1006/bbrc.1993.1343.
A total of 34 different apo(a) isoforms was identified in a population sample of 806 American Whites and 701 American Blacks by a high resolution SDS-agarose gel electrophoretic method followed by immunoblotting. Among the 1507 individuals tested, 79% revealed double-banded phenotypes and 21% single-banded phenotypes. The frequencies of the apo(a) isoforms differed between American Blacks and Whites (p < 0.001).
通过高分辨率SDS-琼脂糖凝胶电泳法继以免疫印迹，在806名美国白人和701名美国黑人的人群样本中，共鉴定出34种不同的载脂蛋白(a)异构体。在1507名受测个体中，79%呈现双条带表型，21%呈现单条带表型。美国黑人和白人的载脂蛋白(a)异构体频率存在差异(p < 0.001)。
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