什么是独特型？
What is an idiotype?
作者信息
Jefferis R
机构信息
Dept of Immunology, Medical School, Edgbaston, Birmingham, UK.
出版信息
Immunol Today. 1993 Mar;14(3):119-21. doi: 10.1016/0167-5699(93)90211-3.
PMID:8466627
Abstract
Idiotypy is an important concept with significant practical implications for the manipulation of B- and T-cell clones. However, this potential depends on a correct identification of idiotypy and the development of appropriate reagents. Current knowledge of the structure and polymorphism within the Ig loci reveals that several idiotypic paradigms are based on isotypic or allotypic structures rather than supposed crossreactive idiotypes.
摘要
独特型是一个重要概念，对B细胞和T细胞克隆的操控具有重大实际意义。然而，这种潜力取决于对独特型的正确识别以及合适试剂的开发。目前对免疫球蛋白基因座内结构和多态性的了解表明，几种独特型范式是基于同种型或同种异型结构，而非所谓的交叉反应性独特型。
Zotero 插件