Rudolph T M, Delay E R
Department of Psychology, Regis University, Denver, CO 80221.
Behav Brain Res. 1993 Feb 26;53(1-2):189-99. doi: 10.1016/s0166-4328(05)80278-5.
In Expt. 1, rats were conditioned to emit a shock avoidance response when the pulse rate of a light was increased. Then, after bilateral visual cortex lesions, the rats were given 10, 20, or 40 days recovery before relearning the discrimination. While all rats were able to relearn the discrimination response, lesion rats had a performance deficit after all recovery periods. Expt. 2 compared the effects of postoperative visual pulse rate training to those of auditory pulse rate training on relearning of the photic pulse-rate discrimination 10 days after visual decortication. Recovery of discrimination responding was better after auditory pulse rate training than after visual training. These data suggest that visual cortex lesions in the rat disrupt perceptual or associational functions involving the temporal features of a visual stimulus. In addition, generalization of relational properties during cross-modal training through multimodal CNS structures appears to enhance recovery of behavior after brain insult.
在实验1中，当灯光的脉冲速率增加时，大鼠被训练发出回避电击的反应。然后，在双侧视觉皮层损伤后，给予大鼠10天、20天或40天的恢复时间，再重新学习辨别任务。虽然所有大鼠都能够重新学习辨别反应，但损伤大鼠在所有恢复期后都存在行为表现缺陷。实验2比较了术后视觉脉冲速率训练和听觉脉冲速率训练对视觉皮层切除术后10天重新学习光脉冲速率辨别的影响。听觉脉冲速率训练后辨别反应的恢复比视觉训练后更好。这些数据表明，大鼠的视觉皮层损伤会破坏涉及视觉刺激时间特征的感知或联想功能。此外，通过多模式中枢神经系统结构进行跨模式训练时关系属性的泛化似乎能增强脑损伤后行为的恢复。
