Richards A M, Tree M, Tonolo G, Montorsi P, Polonia J, Morton J J, Fraser R, Frampton C
MRC Blood Pressure Unit, Western Infirmary, Glasgow, Scotland.
Clin Exp Hypertens. 1993 Mar;15(2):379-94. doi: 10.3109/10641969309032941.
The effects of physiological shifts in plasma atrial natriuretic factor (ANF) concentrations on angiotensin II/aldosterone relationships during changes in sodium status were assessed in 6 conscious beagle dogs. Incremental infusions of angiotensin II (3, 9 and 27ng/kg/min) were administered on three occasions. The animals were studied in sodium replete and deplete states and on a third occasion, again while sodium deplete, with a background constant low-dose infusion of ANF (1.5pmol/kg/min) sufficient to enhance the low endogenous plasma ANF values observed in sodium depletion to match those observed in the sodium replete state. Sodium depletion caused a leftward shift and steepened the slope of the relationship between achieved arterial angiotensin II concentrations and the plasma aldosterone response. This effect was significantly attenuated (approximately 50%) by the low dose ANF infusions which tended to flatten the slope of the angiotensin II/aldosterone curve (ns) and shifted it significantly to the right (p < 0.05). These data suggest subtle shifts in endogenous levels of plasma ANF, accompanying changes in sodium status, are a major contributor to the associated alterations in angiotensin II/aldosterone relationships. Low dose ANF also significantly reduced the effect of angiotensin II on arterial pressures but did not alter natriuresis.
在6只清醒的比格犬身上评估了钠状态改变期间血浆心房利钠因子（ANF）浓度的生理变化对血管紧张素II/醛固酮关系的影响。分三次进行血管紧张素II的递增输注（3、9和27 ng/kg/min）。对动物在钠充足和钠缺乏状态下进行研究，第三次研究时，同样是在钠缺乏状态下，同时进行背景低剂量ANF持续输注（1.5 pmol/kg/min），该剂量足以将钠缺乏时观察到的低内源性血浆ANF值提高至与钠充足状态下观察到的值相匹配。钠缺乏导致已达到的动脉血管紧张素II浓度与血浆醛固酮反应之间的关系向左移动并使斜率变陡。低剂量ANF输注使这种效应显著减弱（约50%），这倾向于使血管紧张素II/醛固酮曲线的斜率变平（无统计学意义）并使其显著右移（p < 0.05）。这些数据表明，伴随钠状态变化的血浆ANF内源性水平的细微变化是血管紧张素II/醛固酮关系相关改变的主要促成因素。低剂量ANF还显著降低了血管紧张素II对动脉压的作用，但未改变利钠作用。
