Haglund M M, Ojemann G A, Lettich E, Bellugi U, Corina D
Department of Neurological Surgery, University of Washington, Seattle 98195.
Brain Lang. 1993 Jan;44(1):19-27. doi: 10.1006/brln.1993.1002.
Based on stroke and other lesion data, the cortical organization of sign language has been shown to be in the verbal language-dominant hemisphere. However, finer detail of the cortical organization of sign language is not readily available. Intraoperative cortical mapping of spoken and American Sign Language (ASL) was performed in a hearing patient proficient in ASL undergoing an awake operation for intractable epilepsy. We found the dissociation of essential cortical language sites for spoken and signed languages, the relationship of these sites to the interpretation of ASL, and the importance of the anterior temporal lobe in the language-dominant hemisphere for proper ASL handshapes. Single unit recordings in the anterior temporal lobe, at a site later identified to be important in handshape formation, showed sustained activity during naming with superimposed increases in activity during overt speech.
基于中风及其他病变数据，手语的皮质组织已被证明位于言语主导半球。然而，手语皮质组织的更精细细节尚难以获取。对一名精通美国手语（ASL）的听力正常患者进行了清醒开颅手术治疗难治性癫痫，术中对其口语和美国手语进行了皮质图谱绘制。我们发现了口语和手语在关键皮质语言区域的分离，这些区域与美国手语解读的关系，以及在语言主导半球中颞叶前部对于正确的美国手语手势形状的重要性。在颞叶前部的单个神经元记录显示，在一个后来被确定对手势形状形成很重要的部位，在命名过程中呈现持续活动，在公开言语期间活动叠加增加。
