Squillante R G, Williams J L
McKay Laboratory of Orthopaedic Surgery Research, University of Pennsylvania School of Medicine, Philadelphia.
Calcif Tissue Int. 1993 Apr;52(4):273-7. doi: 10.1007/BF00296651.
The medial femoral cortices of 10 females with femoral neck fractures and 10 age-matched female autopsy cases were studied using computer-assisted videodensitometry. Radiographic mineral density was determined using the calibration method described by Martin et al. [20]. Measurements were made of porosity, osteon and haversian canal dimensions, and of interstitial and osteon mineral density across the cortical wall of the orthopedic calcar region. There were no differences between the fracture and nonfracture groups in the overall mean mineral density of the bone averaged over the microstructure, excluding pore space, or in the interstitial bone mineral density. The porosity in the fracture group was greater than in the autopsy group, especially in the periosteal region, where the porosity was 2.4 times greater and where there were also 27% fewer osteons per unit area than in the autopsy group (P < 0.05). Mean osteon mineral density was 2.5% higher in the fracture group (P < 0.05) compared with the autopsy group in the endosteal region, and 4% higher in the periosteal region. Osteon and haversian canal areas were also larger in the fracture group, especially in the middle region of the cortical wall (17% and 23%, respectively, P < 0.05).
采用计算机辅助视频密度测定法，对10例股骨颈骨折女性患者及10例年龄匹配的女性尸检病例的股骨内侧皮质进行了研究。使用Martin等人[20]描述的校准方法测定X线片矿物质密度。对骨科股骨矩区域皮质骨壁的孔隙率、骨单位和哈弗斯管尺寸以及骨间质和骨单位矿物质密度进行了测量。在排除孔隙空间后，骨折组和非骨折组在整个微观结构平均骨矿物质密度或骨间质矿物质密度方面没有差异。骨折组的孔隙率高于尸检组，尤其是在骨膜区域，其孔隙率是尸检组的2.4倍，且单位面积骨单位数量比尸检组少27%（P<0.05）。在骨内膜区域，骨折组的平均骨单位矿物质密度比尸检组高2.5%（P<0.05），在骨膜区域高4%。骨折组的骨单位和哈弗斯管面积也更大，尤其是在皮质骨壁的中部区域（分别为17%和23%，P<0.05）。
