Willem P, Saragas E
Department of Hematology, School of Pathology, University of the Witwatesrand Medical School, Parktown, South Africa.
Cancer Genet Cytogenet. 1993 Mar;66(1):75-6. doi: 10.1016/0165-4608(93)90153-d.
We document the clinical, morphologic, and cytogenetic findings in a 2 1/2-year-old patient with acute megakaryoblastic leukemia. Cytogenetic analysis of peripheral blood leukemic cells revealed the presence of a der(11)t(7;11)(q11;q24). Chromosome 7 involvement is observed in nearly half of all cases of megakaryoblastic leukemias, however, the type of abnormality differs widely from one case to another. The der(11)t(7;11)(q11;q24) described here is the first reported to our knowledge.
我们记录了一名2岁半急性巨核细胞白血病患者的临床、形态学和细胞遗传学检查结果。对其外周血白血病细胞进行的细胞遗传学分析显示存在der(11)t(7;11)(q11;q24)。在几乎一半的巨核细胞白血病病例中均观察到7号染色体受累，然而，异常类型在不同病例之间差异很大。据我们所知，此处描述的der(11)t(7;11)(q11;q24)是首次报道。
