急性非淋巴细胞白血病中的一种新的8号染色体臂间倒位。
A new pericentric inv(8) in acute nonlymphocytic leukemia.
作者信息
Santoro A, Carbone P, Caradonna F, Fabbiano F, Mirto S, Caronia F
机构信息
Dipartimento di Ematologia, Ospedale V. Cervello, USL 60, Palermo, Italy.
出版信息
Cancer Genet Cytogenet. 1993 Mar;66(1):77-8. doi: 10.1016/0165-4608(93)90154-e.
Chromosome studies were carried out on unstimulated bone marrow cells from a patient with a diagnosis of acute nonlymphocytic leukemia (FAB M6 ANLL). Cytogenetic analysis revealed a mosaic chromosome pattern 46,XX/46,XX,inv(8)(p21q24). This pericentric inversion has not been previously described in ANLL. Because, fragile sites, zinc finger gene loci, and the MYC protooncogene have been localized to band 8q24, a putative role for these sites and genes could be considered.
对一名诊断为急性非淋巴细胞白血病（FAB M6型急性非淋巴细胞白血病）患者的未受刺激骨髓细胞进行了染色体研究。细胞遗传学分析显示出一种嵌合染色体模式46,XX/46,XX,inv(8)(p21q24)。这种臂间倒位此前尚未在急性非淋巴细胞白血病中被描述过。由于脆性位点、锌指基因座以及MYC原癌基因已定位到8q24带，因此可以考虑这些位点和基因的假定作用。
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