Moussa M A
Department of Community Medicine, Faculty of Medicine & Health Sciences, Al-Ain, United Arab Emirates.
Comput Biol Med. 1993 Jan;23(1):77-82. doi: 10.1016/0010-4825(93)90110-m.
The paper considers the estimation of the potency of an unknown test preparation in relation to a standard in a dilution assay. The method utilizes the Mantel-Haenszel one degree of freedom chi-square approach to test consistency of the observed potency ratio with a range of alternative potency ratios. The method is nonparametric as it does not require any distributional assumptions. However, it requires the doses employed to be equally spaced logarithmically. The dose-response curve is also required to be monotone over the dose range used.
