Hansson M, von Wachenfeldt C
Department of Microbiology, University of Lund, Sweden.
FEMS Microbiol Lett. 1993 Feb 15;107(1):121-5. doi: 10.1016/0378-1097(93)90365-9.
Bacillus subtilis can synthesise cytochromes containing a-, b-, c- and d-type heme. The biosynthetic pathways of these heme prosthetic groups were investigated by using strains blocked in uroporphyrinogen III synthesis from porphobilinogen or in heme b (protoheme IX) synthesis from uroporphyrinogen III. The results strongly suggest that heme a and heme d are both synthesised from heme b (protoheme IX). They also indicate that B. subtilis contains a novel ferrochelatase involved in the synthesis of siroheme.
枯草芽孢杆菌能够合成含有a型、b型、c型和d型血红素的细胞色素。通过使用在从胆色素原合成尿卟啉原III或从尿卟啉原III合成血红素b（原血红素IX）过程中受阻的菌株，研究了这些血红素辅基的生物合成途径。结果有力地表明，血红素a和血红素d均由血红素b（原血红素IX）合成。它们还表明，枯草芽孢杆菌含有一种参与 siroheme 合成的新型铁螯合酶。
