Wong C W, Thong Y H, Seow W K
Department of Child Health, University of Queensland, Mater Childrens Hospital, South Brisbane, Australia.
Int J Immunopharmacol. 1993 Feb;15(2):185-93. doi: 10.1016/0192-0561(93)90094-f.
The bisbenzylisoquinoline analogues, tetrandrine and berbamine, were investigated for their effects on guineapig airway microvascular leakage, an animal model of asthma and allergic inflammation. Significant inhibition of microvascular leakage by tetrandrine was observed with all four allergic mediators used in these experiments. By contrast, berbamine was able to suppress microvascular leakage induced by platelet-activating factor and bradykinin, but not by leukotriene D4 or histamine. These results indicate that tetrandrine has broad-spectrum inhibitory activity on allergic mediators, and may have value for the therapy of diseases in which these mediators have a role in pathogenesis.
研究了双苄基异喹啉类似物粉防己碱和小檗胺对豚鼠气道微血管渗漏（一种哮喘和过敏性炎症的动物模型）的影响。在这些实验中使用的所有四种过敏介质作用下，均观察到粉防己碱对微血管渗漏有显著抑制作用。相比之下，小檗胺能够抑制由血小板活化因子和缓激肽诱导的微血管渗漏，但不能抑制白三烯D4或组胺诱导的渗漏。这些结果表明，粉防己碱对过敏介质具有广谱抑制活性，可能对治疗这些介质在发病机制中起作用的疾病有价值。
