Sager W D, Fueger G F, Thalhamer M
Nuklearmedizin. 1977 Feb;16(1):18-25.
Quantitative regional measurements of the distribution of a bone seeking radiopharmaceutical is performed easily together with a bone scan using a scintillation camera. Comparative measurements of regional radioactivities yield a ratio of relative uptake. The time change of such a relative uptake ratio is obtained by repeating the regional comparison measurements after a 4--8 weeks interval. The time change of the relative uptake ratio was found to be a clinically useful parameter in the follow-up of skeletal diseases. A decrease in the relative uptake ratio was found with healing fractures, with receding osteomyelitis and during radiation therapy of bone metastases; an increase was observed with spreading metastases, developing osteomyelitis, developing pseudathrosis, and in the beginning of normal fracture healing.
使用闪烁相机进行骨扫描时，可轻松地同时对亲骨性放射性药物的分布进行定量区域测量。区域放射性的比较测量可得出相对摄取率。通过在4至8周的间隔后重复进行区域比较测量，可获得这种相对摄取率随时间的变化情况。结果发现，相对摄取率随时间的变化在骨骼疾病的随访中是一个具有临床实用价值的参数。在骨折愈合、骨髓炎消退以及骨转移瘤放疗期间，相对摄取率会降低；而在转移瘤扩散、骨髓炎发展、假关节形成以及正常骨折愈合初期，相对摄取率会升高。
