睾酮从栓剂基质中的体外释放及在男性体内的吸收研究。

In vitro release of testosterone from suppository bases and in vivo absorption studies in human males.

作者信息

Babar A, Fares H M, Plakogiannis F M

机构信息

Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201.

出版信息

J Pharm Sci. 1993 Apr;82(4):389-91. doi: 10.1002/jps.2600820411.

DOI:10.1002/jps.2600820411

PMID:8468682

Abstract

Diffusion rates of testosterone from various suppository bases with and without surfactants were determined. In a limited study, selected suppository formulations were evaluated for efficiency of rectal absorption of testosterone in three male volunteers ranging in age from 25 to 30 years. Significant reductions in the ratios of urinary metabolites to free testosterone were observed with polyethylene glycol 1000, esterified (C10-C18) fatty acids, and theobroma oil-based samples.

摘要

测定了睾酮在有无表面活性剂的情况下从各种栓剂基质中的扩散速率。在一项有限的研究中，对选定的栓剂制剂在三名年龄在25至30岁之间的男性志愿者中进行了睾酮直肠吸收效率的评估。观察到聚乙二醇1000、酯化（C10 - C18）脂肪酸和可可脂基样品的尿代谢物与游离睾酮的比率显著降低。