Ohno K, Itoh K, Nagao K, Katoh H, Okushiba T, Satoh M, Tomiyama M, Hiraguchi E, Tanabe T
Second Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan.
Kaku Igaku. 1993 Feb;30(2):217-24.
A clinical study with 99mTc-DTPA-galactosyl serum albumin (99mTc-GSA) was performed in 10 patients with hepatobiliary disease. In this study, scintigraphic data and images with 99mTc-GSA were compared with several serological liver function tests, the hepatic blood perfusion index and image quality using 99mTc-DTPA-human serum albumin (99mTc-HSA). Dynamic and serial hepatic images were obtained over a 20 min period after 99mTc-GSA injection, and time activity curves from the heart and liver were generated. The blood clearance index (HH15), and the hepatic uptake index (LHL15) were calculated from each curve of the heart and liver, respectively. In addition, using two compartment fitting, the blood clearance (KH1, KH2) index was calculated, and using exponential fitting, the hepatic uptake index (KL) was calculated. The mean HH15 in LC group and non-LC group was 0.81 +/- 0.05, 0.64 +/- 0.10, respectively. The mean LHL15 in LC group and non-LC group was 0.79 +/- 0.04, 0.91 +/- 0.06, respectively. There were significant differences between non-LC group and LC group in HH15, and LHL15, KH1 and KL. There were also significant correlations of KH1 with HH15, and KL with LHL15. Parameters of 99mTc-GSA showed significant correlations with various liver functions. 99mTc-GSA scintigraphy showed clearer liver images in hepatobiliary diseases than 99mTc-HSA. These results suggest that 99mTc-GSA scintigraphy is useful in estimating preserved liver function and hepatic morphology.
对10例肝胆疾病患者进行了一项使用99mTc - DTPA - 半乳糖基血清白蛋白（99mTc - GSA）的临床研究。在本研究中，将99mTc - GSA的闪烁扫描数据和图像与几种血清肝功能检查、肝血流灌注指数以及使用99mTc - DTPA - 人血清白蛋白（99mTc - HSA）的图像质量进行了比较。在注射99mTc - GSA后的20分钟内获取动态和系列肝脏图像，并生成心脏和肝脏的时间 - 活性曲线。分别从心脏和肝脏的每条曲线计算出血清清除指数（HH15）和肝脏摄取指数（LHL15）。此外，使用双室拟合计算血清清除（KH1、KH2）指数，使用指数拟合计算肝脏摄取指数（KL）。LC组和非LC组的平均HH15分别为0.81±0.05、0.64±0.10。LC组和非LC组LHL平均15分别为0.79±0.04、0.91±0.06。非LC组与LC组在HH15、LHL15、KH1和KL方面存在显著差异。KH1与HH15、KL与LHL15也存在显著相关性。99mTc - GSA的参数与各种肝功能显示出显著相关性。99mTc - GSA闪烁扫描在肝胆疾病中显示的肝脏图像比99mTc - HSA更清晰。这些结果表明，99mTc - GSA闪烁扫描在评估肝脏储备功能和肝脏形态方面是有用的。
