Yoshii C, Hamada M, Tao Y, Sasaki M, Okamoto T, Obata H, Nikaido Y, Nagata N, Shirakusa T, Kido M
Division of Respiratory Disease, University of Occupational and Environmental Health, Kitakyushu, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Jan;31(1):117-22.
A 61-year-old man was admitted to our hospital on October 8, 1991 because of abnormal shadows on chest X-ray at annual checkup at his company. Chest X-ray and CT on admission showed diffuse reticular shadows in bilateral lower lung fields and a nodular opacity approximately 10 mm in diameter in the right lower lung. Since transbronchial lung biopsy was not diagnostic, an open lung biopsy was performed on October 28, 1991. The lung specimens showed diffuse pulmonary fibrosis compatible with usual interstitial pneumonia and an intrapulmonary lymph node containing silicotic nodules. Only 29 cases (including the present case) of intrapulmonary lymph nodes have been reported. Although the causes of intrapulmonary lymph nodes are not clear, smoking is considered to play an important role in the development of pulmonary lymphoid tissue. In our case, the intrapulmonary lymph node contained silicotic nodules. Only several case have been reported to have silicotic nodules in the lymph nodes. As suggested by Kradin, they may be induced by relatively low levels of exposure to dust. Our case also had pulmonary fibrosis (IIP), and is the first reported case of intrapulmonary lymph node associated with IIP. Although it is difficult to determine these two diseases occurred coincidently or not, it is possible that a low level of dust exposure may have contributed to both silicotic nodules in the lymph node and IIP.
一名61岁男性因在公司年度体检时胸部X线出现异常阴影于1991年10月8日入住我院。入院时胸部X线和CT显示双下肺野弥漫性网状阴影,右下肺有一个直径约10mm的结节状致密影。由于经支气管肺活检未能明确诊断,于1991年10月28日行开胸肺活检。肺标本显示符合寻常型间质性肺炎的弥漫性肺纤维化以及一个含有矽肺结节的肺内淋巴结。肺内淋巴结仅报道过29例(包括本例)。虽然肺内淋巴结的病因尚不清楚,但吸烟被认为在肺淋巴组织的发生中起重要作用。在我们的病例中,肺内淋巴结含有矽肺结节。仅有几例报道淋巴结中有矽肺结节。如Kradin所指出的,它们可能由相对低水平的粉尘接触诱发。我们的病例也有肺纤维化(特发性间质性肺炎),是首例报道的与特发性间质性肺炎相关的肺内淋巴结病例。虽然很难确定这两种疾病是否同时发生,但低水平的粉尘接触可能导致了淋巴结中的矽肺结节和特发性间质性肺炎。