[Affinity alkylation of E. coli RNA-dependent DNA polymerase with TTP gamma-amidate derivatives].
作者信息
Buneva V N, Kudriushova N V, Kurbatov V A, Romsshchenko A G
出版信息
Biokhimiia. 1978 Dec;43(12):2261-4.
PMID:84690
Abstract
TTP gamma-benzylamidates are shown to act as competitive inhibitors of poly(dT) synthesis catalyzed by E. coli RNA-dependent DNA polymerase. The KM value for TTP as well as KI values for the gamma-analogues have been determined. TTP gamma-4-(N-2-chloroethyl-N-methyl-amino)benzylamidate is shown to be an effective affinity reagent for this enzyme.
摘要
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